In February 2026, the ISOLPHARM collaboration acquired, for the first time, a SPECT/CT image of 111Ag using a clinical system. The radionuclide was produced at LENA nuclear reactor in Pavia, and subsequently transported to the Arcispedale S. Maria Nuova in Reggio Emilia. Health Physics and Radiochemistry teams from this hospital and from the IRST “Dino…
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On December 18th, the ISOLPHARM 2025 annual meeting took place at the Legnaro National Laboratories of INFN. The Work Packages of the SPES_MED, ADMIRAL and ISOLPHARM_CORE experiments showed their latest results according to the scheduled milestones. All presentations are available on the event’s Indico page. Thank you to all the participants!
Two new papers were published by the ISOLPHARM collaboration in July 2025. Both articles belong to the WP4 activities of the ADMIRAL experiment, dealing with radiobiology and radiation biophysics. The first one, entitled “Monte Carlo dosimetry of silver-111 in simplified cell geometries in the framework of the ISOLPHARM project” and published by the journal Applied…
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In May 2025 the WP3 of the ADMIRAL experiment performed a characterization test of the gamma camera using Ag-111 produced at LENA, Pavia. For the first time a mouse phantom was employed to simulate the case of an in-vivo experiment. Big thanks to the LENA personnel!
On December 12th, the ISOLPHARM 2024 annual meeting took place at the Legnaro National Laboratories of INFN. The Work Packages of the ADMIRAL and ISOLPHARM_CORE experiments showed their latest results according to the scheduled milestones, while the new SPES_MED experiment was kicked off. All presentations are available on the event’s Indico page. Thank you to…
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The 3D scaffold bioprinting experiments for the ISOLPHARM project started at the beginning of 2024 with some geometry printing tests, where GelMa was cured under a DLP homemade printer with the main task of testing the printing resolution of the instrument. At the end of October the first test where the ink was a mixture…
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In October 2024, the ISOLPHARM collaboration successfully performed the first clonogenic survival evaluation using silver-111 on cancer cells. In particular, the UMR-106 rat osteosarcoma cell line was tested. This result represents a first important experimental milestone reached by the ISOLPHARM radiobiology community, which includes groups from the Universities of Pavia (with the LENA facility), Padova,…
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At the CAPiR lab of Catania a solution containing Ag-111 was injected in mice. The Bruker In-Vivo Xtreme was then used to acquire digital autoradiography images after several time points. This is the first time in which the collaboration acquires in-vivo images through the Ag-111 radiation.
A new publication entitled “Ag-111 phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project” have just been published in the journal Applied Radiation and Isotopes. This paper describes the imaging experiments performed with phantoms filled with Ag-111 produced at LENA in Pavia and imaged by the Bruker In-Vivo Xtreme device at…
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The ISOLPHARM project 2023 annual meeting was held at the Legnaro National Laboratories of INFN on December 21st. The four Work Packages of ADMIRAL experiment presented their progress according to the planned milestones. All contributions are available on the event’s Indico page. Thanks to all the partecipants!
