D. Serafini et al – Ag-111 phantom images with Cerenkov Luminescence Imaging and digital autoradiography within the ISOLPHARM project
1 file(s) 1.79 MB
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2023

M. Tosato – Chromatographic separation of silver-111 from neutron-irradiated palladium target: toward direct labeling of radiotracers
1 file(s) 1.56 MB
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O.S. Khwairakpam et al., Resonant Laser Ionization and Fine-Structure Study of Silver in an Ablation Plume
1 file(s) 997.76 KB
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L. Morselli et al., Production and characterization of Ag-111 radioisotope for medical use in a TRIGA Mark II nuclear research reactor
1 file(s) 2.84 MB
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M. Tosato et al., Lights and Shadows on the Sourcing of Silver Radioisotopes for Targeted Imaging and Therapy of Cancer: Production Routes and Separation Methods
1 file(s) 6.80 MB
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A. Arzenton – Radiobiological model for β-emitter radiopharmaceutical therapy in dynamic cell cultures in the framework of the ISOLPHARM project
1 file(s) 407.66 KB
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2022

M. Tosato et al., Chelation of Theranostic Copper Radioisotopes with S-Rich Macrocycles: From Radiolabelling of Copper-64 to In Vivo Investigation
1 file(s) 3.77 MB
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M. Tosato et al., When ring makes the diﬀerence: coordination properties of Cu 2+ /Cu + complexes with sulfur-pendant polyazamacrocycles for radiopharmaceutical applications
1 file(s) 2.61 MB
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V. Benfante et al, A New Preclinical Decision Support System Based on PET Radiomics: A Preliminary Study on the Evaluation of an Innovative 64Cu-Labeled Chelator in Mouse Models
1 file(s) 28.78 MB
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O.S. Khwairakpam et al., Laser photo-ionization study of natAg using opto-galvanic signal at SPES offline laser lab
1 file(s) 439.00 KB
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E. Vettorato et al., A new production method of high specific activity radionuclides towards innovative radiopharmaceuticals: the ISOLPHARM project
1 file(s) 549.85 KB
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A. Zanini et al., Sucrose-based sol-gel synthesis of microporous titanium carbide as target material for the production of radioisotopes
1 file(s) 7.72 MB
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2021

M. Ballan et al. – Development of implantation substrates for the collection of radionuclides of medical interest produced via ISOL technique at INFN-LNL
1 file(s) 5.59 MB
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M. Tosato et al. Copper Coordination Chemistry of Sulfur Pendant Cyclen Derivatives: An Attempt to Hinder the Reductive-Induced Demetalation in 64/67 Cu Radiopharmaceuticals
1 file(s) 2.44 MB
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M. Verona et al. Preliminary Study of a 1,5-Benzodiazepine-Derivative Labelled with Indium-111 for CCK-2 Receptor Targeting
1 file(s) 4.39 MB
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2020

M. Tosato et al. Chemical purification of 111-Ag from isobaric impurity 111-Cd by solid phase extraction chromatography: a proof of concept study
1 file(s) 350.41 KB
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M. Tosato et al. Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms
1 file(s) 2.08 MB
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M. Ballan et al Preliminary evaluation of the production of non-carrier added 111-Ag as core of a therapeutic radiopharmaceutical in the framework of ISOLPHARM_Ag experiment
1 file(s) 6.28 MB
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V. Di Marco et al. pH-static titrations for kinetic studies of metal-ligand complex formation: The case example of the reaction between Strontium(II) and DOTA
1 file(s) 335.34 KB
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S. Corradetti, A. Andrighetto, The ISOLPHARM Project: Production of High Specific Activity Medical Radioisotopes at SPES, 2020
1 file(s) 779.38 KB
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M. Tosato et al., Toward novel sulphur-containing derivatives of tetraazacyclododecane: synthesis, acid–base properties, spectroscopic characterization, DFT calculations, and cadmium(II) complex formation in aqueous solution, 2020
1 file(s) 3.05 MB
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2019

A.Andrighetto et al., The ISOLPHARM project: ISOL-based production of radionuclides for medical applications, 2019
1 file(s) 871.56 KB
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A. Andrighetto et al. ISOLPHARM, a new production method of high specific activity beta-emitting radionuclides as radiopharmaceutical precursors
1 file(s) 164.97 KB
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2018

F.Borgna et al., Early Evaluation of Copper Radioisotope Production at ISOLPHARM, 2018
1 file(s) 7.95 MB
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A. Andrighetto et al. The ISOLPHARM project: A New ISOL production method of high specific activity beta-emitting radionuclides as radiopharmaceutical precursors
1 file(s) 1.59 MB
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A. Andrighetto et al. A Novel Methods FGor The Production Of Radionuclides Of Medical Interest With Accelerators
1 file(s) 475.40 KB
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2017

F.Borgna et al., A preliminary study for the production of high specific activity radionuclides for nuclear medicine obtained with the isotope separation on line technique, 2017
1 file(s) 1.72 MB
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Posters

2023

D. Serafini, A. Arzenton et al., The Resonant Ionization Laser Ion Source @ SPES-ISOLPHARM
1 file(s) 6.65 MB
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2022

O.S. Khwairakpam et al., Laser Photo-Ionization of natAg in the SPES offline laser lab, INFN-LNL (Application in the Radioactive Ion Beam facility)
1 file(s) 728.81 KB
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2021

L. Morselli et al. – The ISOLPHARM collaboration : a facility for the production and study of innovative radiopharmaceuticals
1 file(s) 4.30 MB
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2020

Nardella S. et al., Chemical purification of 111-Ag from isobaric impurity 111-Cd by solid phase extraction chromatography, VIII GICR National Congress, September 18 th, 19th 2020, Padova, Italy
1 file(s) 1.97 MB
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Verona M. et al., Radiolabeling and preliminary in vivo study of a small molecule-based ligand for CCK2 receptors targeting, VIII GICR National Congress, September 18 th, 19th 2020, Padova, Italy
1 file(s) 1,008.42 KB
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Ballan M. et al., Collection targets for the ISOLPHARM project, VIII GICR National Congress, September 18 th, 19th 2020, Padova, Italy
1 file(s) 1.14 MB
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Morselli L. et al., Study of 111-Ag production via the 110-Pd(n,γ) 111-Ag reaction, VIII GICR National Congress, September 18 th, 19th 2020, Padova, Italy
1 file(s) 520.40 KB
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Corradetti S. et al., The ISOLPHARM_EIRA INFN experiment, VIII GICR National Congress, September 18 th , 19 th 2020 Padova, Italy
1 file(s) 1.23 MB
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2019

Zangrando L. et al., ISOLPHARM_Ag Simulazioni Monte Carlo con Kubernetes, Workshop della commissione Calcolo dell’ INFN, LA Biodola, Isola d’Elba, 3-7 Giugno 2019
1 file(s) 370.60 KB
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Caeran M. et al., Progetto Isolpharm_Ag: Produzione di 111Ag e progettazione di radiofarmaci a scopo terapeutico, 59° Simposio AFI, Rimini, 5-7 Giugno 2019
1 file(s) 1.43 MB
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M.Tosato, MEDICIS-Promed Final Conference, Erice, 29-4 May 2019
1 file(s) 5.52 MB
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Corradetti S. et al., The ISOLPHARM Project: ISOL-based production of radioisotopes fo medical applications, Joint LIA COLL‐AGAIN, COPIGAL, and POLITA Workshop (French-Italian-Polish Collaborations) 5-7 March 2019 Heavy Ion Laboratory University of Warsaw, Warsaw, Poland
1 file(s) 6.34 MB
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2018

Ballan M. et al., Production target concepts for the SPES – ISOLPHARM project, EURISOL, Pisa, 2-4 Luglio 2018,
1 file(s) 1.61 MB
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Ferrari M. et al., ISOLPHARM: new ISOL-production method of high specific activity beta-emitting radionuclides as radiopharmaceutical precursors, RAD 2018, Ohrid, Macedonia (FYROM), 18th-22th June 2018
1 file(s) 6.25 MB
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Corradetti S. et al., Development of targets for the production of radionuclides at the ISOLPHARM project, VII GICR National Congress May 11 th , 12 th 2018 Ferrara, Italy
1 file(s) 2.08 MB
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Verona M. et al., Synthesis of small molecule-based ligands for active targeting of CCK2R for the ISOLPHARM-Ag project, VII GICR National Congress May 11 th , 12 th 2018 Ferrara, Italy
1 file(s) 853.92 KB
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Favaretto C. et al., Production of carrier-free copper radionuclides with the ISOLPHARM method for nuclear medicine, VII GICR National Congress May 11 th , 12 th 2018 Ferrara, Italy
1 file(s) 2.40 MB
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Borgna F. et al., ISOLPHARM_Ag project: production and purification of silver ion beams for 111Ag production, VII GICR National Congress – May 11th, 12th 2018 – Ferrara, Italy
1 file(s) 7.54 MB
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Ballan M. et al.,Target concepts for the production of radionuclides of medical interest for the ISOLPHARM Project, VII GICR National Congress – May 11 th , 12 th 2018 – Ferrara, Italy
1 file(s) 1.81 MB
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2016

D’Odorico G. et al., Synthesis and Characterization of Sodium Nonatitanate Ion Exchanger (Na4Ti9O20 ∙ xH2O) for 90Sr removal from 90Y, A.It.UN., Parma, Maggio 2016
1 file(s) 3.95 MB
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Todesco C. et al., Design of pharmaceutical process for the deposition and recovery of Iodine from an accelerated ion beam obtained with isotopes separation on-line method (ISOL), A.It.UN, Parma, Maggio 2016
1 file(s) 2.82 MB
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Vettorato E. et al., Chemical separation of Strontium from Yttrium for the preparation of high radionuclidic purity 90Y produced with the ISOL technique for innovative radiopharmaceuticals, A.It.UN., Parma, Maggio 2016
1 file(s) 3.44 MB
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2015

Borgna F. et al., Research and technological development of b- emitting radiopharmaceuticals produced with radioactive ion beams, 55° AFI Simposium, Rimini, 2015
1 file(s) 2.74 MB
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Ph.D. & Master Thesis

PhD Theses

2024

A. Arzenton – Towards 111Ag as a medical radionuclide: from production and laser photo-ionisation to cell dosimetry and radiation biophysics in the context of the ISOLPHARM project

1 file(s) 11.93 MB

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2023

L. Morselli – Production and Characterization of Ag-111 for radiopharmaceutical applications in the framework of the ISOLPHARM project

1 file(s) 123.59 MB

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2019

Ballan M., Development of targets for the production of radionuclides of medical interest according to the ISOL technique, XXXI series, 2019

1 file(s) 14.58 MB

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2018

Borgna F., Pharmaceutical development of the ISOL technique for the production of radionuclides and their applications in targeted radionuclide therapy, XXX series, 2018

1 file(s) 6.44 MB

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Master Degree Theses

2024

F. Nicente – Screening e sviluppo tecnologico di target di deposizione innovativi per la raccolta di radionuclidi medicali nell’ambito del progetto ISOLPHARM

1 file(s) 5.90 MB

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2023

V. Pavanello – Performance study of a novel 2D imaging beta detector for medical applications

1 file(s) 16.04 MB

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N. Zancopè – Analysis and interpretation of CLI and DRI images in view of a Ag-111 biodistribution experiment

1 file(s) 33.79 MB

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A. Leso – Study of DNA damage by beta radiation using Geant4-DNA in the context of the ISOLPHARM project

1 file(s) 12.98 MB

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E. Reniero – Cellular dosimetry using Geant4 in the context of the ISOLPHARM project

1 file(s) 19.30 MB

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2022

L. Compagno – Sviluppo e caratterizzazione di target di deposizione e validazione del sistema ISOLPHARM Radionuclide Implatation Station (IRIS) nell’ambito del progetto ISOLPHARM

1 file(s) 2.31 MB

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D. Serafini – Monte-Carlo simulations for medical images interpretation in the context of the ISOLPHARM project

1 file(s) 25.67 MB

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F. Dian – Sintesi di un nuovo chelante azamacrociclico con relativa caratterizzazione in vitro per la determinazione delle pKa

1 file(s) 2.89 MB

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G. Colombara – Sintesi e caratterizzazione di nuovi chelanti azamacrociclici rigidificati utilizzabili in terapia radiofarmaceutica

1 file(s) 2.25 MB

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F. Speziani – Liposomes engineering for tumor-selective delivery of radionuclides

1 file(s) 2.49 MB

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2021

G. Moretto – Formulazione e Screening di Sistemi Macromolecolari e Vescicolari per il Direzionamento Attivo di Radionuclidi Terapeutici nel Progetto ISOLPHARM

1 file(s) 2.67 MB

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G. De Pizzol – Sviluppo Tecnologico di nuovi Target di Deposizione di Radionuclidi per la Tecnica ISOL

1 file(s) 4.73 MB

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M. Pelosato – Complessi di Cu(II) e Cu(I) con Derivati Solforati di Poliazamacrocicli Aventi Interesse Radiofarmaceutico

1 file(s) 6.47 MB

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S. Franchi – Studio della Formazione di Complessi di Ag(I) e Cd(II) con Derivati Solforati di Poliazacicloalcani

1 file(s) 3.28 MB

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A. Arzenton – Monte Carlo based dosimetry using PET/CT and SPECT/CT imaging in radiopharmaceutical therapy in the context of the ISOLPHARM project

1 file(s) 3.70 MB

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Crocetta F. – Design of Cell-Laden Gelatin Methacryloyl Based Hydrogels For In Vitro Testing Of Radiopharmaceutical

1 file(s) 34.34 MB

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2020

Martini D., Progettazione e sviluppo di un sistema di raccolta e movimentazione di bersagli per la deposizione di isotopi radioattivi di interesse medico

1 file(s) 14.04 MB

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Berberi E., Studio della formazione di complessi tra Cu(II) e derivati del Tetraazaciclododecano di interesse radiofarmaceutico (progetto ISOLPHARM), A.A. 2019-20

1 file(s) 1.61 MB

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Abazi S., Sintesi e veicolazione di radiofarmaci nell’ambito del progetto ISOLPHARM, aventi Nastorazepide come direzionante, A.A. 2019-20

1 file(s) 2.08 MB

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Poloniato A., Formulazione e validazione di target per la deposizione di 111Ag nell’ambito del progetto ISOLPHARM, A.A. 2019-20

1 file(s) 17.68 MB

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2019

Nardella S., Sviluppo di metodi di separazione di Ag(I) dal contaminante isobarico Cd(II) per la produzione di radionuclidi ad uso terapeutico, A.A. 2018-19

1 file(s) 3.72 MB

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Pedrolo C., Linker idrofilici condizionanti la farmacocinetica e la farmacodinamica di ligandi per radioisotopi nell’ambito del progetto ISOLPHARM, A.A. 2018-19

1 file(s) 2.78 MB

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Realdon F., Progetto ISOLPHARM: sintesi di chelanti bifunzionali per radionuclidi di interesse farmaceutico, A.A. 2018-19

1 file(s) 1.39 MB

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Sturaro N., Sviluppo tecnologico di un target secondario innovativo per la deposizione di radioisotopi ad uso medico e studio preliminare della ionizzazione di Tb nell’ambito del progetto ISOLPHARM, A.A. 2018-19

1 file(s) 4.83 MB

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Doro R., Studio della formazione di complessi di Argento(I), Cadmio(II) e Rame(II) con derivati tioeterei del 1,4,7,10-Tetraazaciclododecano per possibili applicazioni in medicina nucleare, A.A. 2018-19

1 file(s) 10.04 MB

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2018

Mengarelli D., Sviluppo di un target refrattario mesoporoso in carburo di titanio per applicazioni in fisica e medicina nucleare, A.A. 2017-18

1 file(s) 7.78 MB

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Caeran M., Progetto Isolpharm_Ag: Ionizzazione, deposizione e purificazione dell’ 111Ag per la produzione di radiofarmaci ad uso terapeutico, A.A. 2017-18

1 file(s) 23.86 MB

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Verona M., Sintesi e caratterizzazione di molecole per il targeting attivo sul recettore CCK2R, A.A. 2017-18

1 file(s) 1.45 MB

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Tosato M., Sintesi e studio termodinamico di nuovi possibili chelanti bifunzionali per la targeted radionuclide therapy con 111Ag (progetto Isolpharm_Ag), A.A. 2017-18

1 file(s) 7.71 MB

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Quaggiotto G., Progetto Isolpharm_Ag: Sviluppo tecnologico di un processo farmaceutico per la produzione di 111Ag e relativa purificazione, A.A. 2017-18

1 file(s) 3.08 MB

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2017

Pellizzola M., Ricerca di un metodo di purificazione dello 89Sr dal suo contaminante 89Y per lo sviluppo tecnologico di un radiofarmaco e ionizzazione dello 45Sc con la tecnologia Isotope Separation On-Line (ISOL)

1 file(s) 3.97 MB

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Favaretto C., Sviluppo tecnologico di un prototipo di generatore 90Sr/90Y e determinazione dell’efficienza di deposizione di 63Cu per radionuclidi prodotti con tecnologia ISOL, A.A. 2016-17

1 file(s) 23.32 MB

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2016

Vettorato E. Studio dello scambiatore ionico Nonatitanato per la purificazione di un radiofarmaco a base di 90Y dal contaminante 90Sr, prodotto con tecnologia ISOL, A.A. 2015-16

1 file(s) 4.47 MB

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Todesco C., Sviluppo di un processo farmaceutico per la produzione di 131I e 125I con tecnologia ISOL (Isotope Separation On-Line), AA. 2015-16

1 file(s) 8.59 MB

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D’Odorico G., Sviluppo preliminare di una preparazione radiofarmaceutica contenente 90YCl3 mediante tecnologia Isotope Separation On Line (ISOL), A.A. 2015-16

1 file(s) 5.85 MB

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2014

Borgna F., Potenzialità della tecnologia Isotope Separation On Line (ISOL) per la realizzazione di un radiofarmaco a base di 89Sr e preliminare sviluppo tecnologico della forma farmaceutica, A.A. 2013-14

1 file(s) 3.08 MB

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Bachelor Thesis

2024

C. Guerrini – Gestione amministrativa e finanziaria dei Laboratori Nazionali di Legnaro dell’INFN

1 file(s) 2.89 MB

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2022

G. Zago – Sviluppo di un rivelatore beta di grande area basato sui chip ALPIDE per il progetto ISOLPHARM

1 file(s) 5.12 MB

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M. Lijoi – Misure di biodistribuzione di molecole caricate a Cu-64 per l’esperimento ISOLPHARM

1 file(s) 1.33 MB

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2021

A. Leso – Studio dei radionuclidi prodotti al reattore LENA per il progetto ISOLPHARM_EIRA

1 file(s) 2.25 MB

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M. Panarelli – Misure di microdosimetria per il progetto ISOLPHARM_EIRA

1 file(s) 37.82 MB

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S. Sughi – Modellazione della produzione del radioisotopo Ag-111 a scopo medico in un reattore nucleare

1 file(s) 1.82 MB

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C. Pantouvakis – Caratterizzazione e primi test con il rivelatore gamma HPGe per la misura della produzione di Ag-111 nel progetto ISOLPHARM di produzione innovativa di radiofarmaci

1 file(s) 4.22 MB

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D. Pavone – Simulazione del sistema spettroscopico di misura della produzione di Ag-111 nel progetto ISOLPHARM di produzione innovativa di radiofarmaci

1 file(s) 12.00 KB

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2019

A. Arzenton – Studio dell’attività dei radionuclidi prodotti dal bersaglio SPES-ISOLPHARM

1 file(s) 1.20 MB

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Meetings

ISOLPHARM_ADMIRAL meetings (2023-25)

General meetings

1. ISOLPHARM_ADMIRAL Kick-off Meeting, 21 Dec 2022

Work Package 1 meetings

1. Work Package 1 meeting, 06 Mar 2023

Work Package 2 meetings

1. Work Package 2 & 4 meeting, 29 May 2023

Work Package 3 meetings

1. Work Package 3 meeting, 20 Jun 2023

Work Package 4 meetings

1. Work Package 2 & 4 meeting, 29 May 2023

ISOLPHARM_EIRA meetings (2020-22)

General meetings

1. ISOLPHARM_EIRA Kick-off Meeting, 29 Nov 2019

2. Plenary meeting – End 2020, 14 Dec 2020

3. Plenary meeting – End 2021, 16 Dec 2021

4. Plenary meeting – End 2022, 21 Dec 2022

Task 1 meetings

1. Task 1 meeting, 06 Apr 2020

2. Task 1 meeting, 15 Jul 2020

3. Task 1 meeting, 22 Apr 2021

4. Task 1 meeting, 21 Oct 2021

5. Task 1 meeting, 12 Jul 2022

Task 2 meetings

1. Task 2 meeting, 24 Apr 2020

2. Task 2 meeting, 30 Jul 2020

3. Task 2 meeting, 29 Mar 2021

4. Task 2 meeting, 19 Oct 2021

5. Task 2 meeting, 18 Jul 2022

Task 3 meetings

1. Task 3 meeting, 06 Feb 2020

2. Task 3 meeting, 29 Jul 2020

3. Task 3 meeting, 12 Apr 2021

4. Task 3 meeting, 26 Oct 2021

5. Task 3 meeting, 22 Jul 2022

ISOLPHARM_Ag meetings (2018-19)

General meetings

1. ISOLPHARM_Ag Kick-off Meeting, 12 Feb 2018

2. Plenary meeting – End 2018, 26 Nov 2018

3. Plenary meeting – End 2019, 29 Nov 2019

Task 1 meetings

1. Task 1 meeting, 05 Dec 2017

2. Task 1 meeting, 28 Mar 2018

3. Task 1 meeting, 30 May 2018

4. Task 1 meeting, 12 Jul 2018

5. Task 1 meeting, 19 Oct 2018

6. Task 1 meeting, 16 Mar 2019

Task 2 meetings

1. Task 2 meeting, 29 Mar 2018

2. Task 2 meeting, 08 Jun 2018

3. Task 2 meeting, 18 Feb 2019

Task 3 meetings

1. Task 3 meeting, 03 Apr 2018

2. Task 3 meeting, 26 Jun 2018

3. Task 3 meeting, 27 Feb 2019

Meetings with students

2021-04-21 – Isolpharm Meeting

1 file(s) 80.27 MB

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2019-10-18 Isolpharm meeting

1 file(s) 10.33 MB

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Data

ISOLPHARM_ADMIRAL data: https://drive.google.com/drive/folders/1w_LMegVgiDjnNjKNP7VV47OKryYM3fFo

ISOLPHARM_EIRA data: https://drive.google.com/drive/folders/1Nu9MTytfqf7_AgviClFmL4S-WANEGYUj

C.F. 84001850589

email: isolpharm at lnl.infn.it

Accessibility

Isolpharm

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